Registration Dossier
Registration Dossier
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EC number: 203-953-2 | CAS number: 112-27-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Original data/studies for this endpoint are not available.
After a single oral administration of 22.5 mg 14C-TEG to four male rats, 86.1 -94% of radioactivity were excreted in urine, 2.0 -5.3 via feces and 0.8 -1.2% via exhaled CO2 within 5 days (McKennis et al., 1962).
Following a single oral administration of 200 mg/kg TEG to one female rabbit, 34.3% of the dose were recovered as unmetabolized TEG in the 24 -hour urine. After 3 consecutive daily oral doses of 2000 mg/kg to one female rabbit, ca. 28% of the original dose were recovered as unmetabolized TEG in the urine, while 35.2% were recovered as "hydroxyacid" metabolite.
The authors stated that the test substance is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. The test substance metabolism by alcohol dehydrogenase can be inhibited, e.g. by 4-methylpyrazole or ethanol.
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