Registration Dossier
Registration Dossier
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EC number: 203-680-9 | CAS number: 109-55-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
Additional information
In order to assess the toxicity of 3 -aminopropyldimethylamine (DMAPA; CAS 109 -55 -7) to microorganisms there are experimental data for the substance itself as well as for the structurally similar substance 3 -aminopropyldiethylamine (DEAPA; CAS 104 -78 -9) available. In accordance with REACH Guidance Document Ch. R.7b (Version 4.0, June 2017; R.7.8.19.1), to assess the toxicity on STP microorganisms, tests with mixed inoculum are preferred over single species tests. Therefore, the study according to OECD 209 with the read-across substance is selected as key study.
As key study, a study with the structurally similar substance 3 -aminopropyldiethylamine (CAS 104 -78 -9) was selected. The study was performed according to OECD 209 (1993) and GLP to determine the effect of the test substance on the oxygen consumption of microbial-inoculum, compared to the blank control. The test was conducted at concentrations of 0 (control) and 1000 mg/L. The toxicity of the test substance was followed by exposing it to activated sludge from a domestic wastewater treatment plant over 30 minutes. All validation criteria were fulfilled. The pH value of the test solutions was neutralised. Based on the results, the EC20 value and the EC50 value were calculated to be greater than 1000 mg/L (BASF SE 2005, report no.: 08G0264/053084).
The result was supported by two growth inhibition studies (non-GLP) with Pseudomonas putida according to the German Industrial Standard DIN 38412-8 for DMAPA (BASF AG, 1987, report no.: 9/0556/87) and DEAPA (BASF AG, 1987, report no.: 99/0784/87).
The stability of the test substances in the test media has not been analytically verified, but is considered to be stable due to the high water solubility, the low Henry's law constant and the low adsorption potential (log Kow and log Koc < 3) of both substances. The efect values are very similar for both substances. The EC10 (17h) was derived to be 69.5 mg/L for DMAPA and 76.1 mg/L (nominal). The 17-h EC50 is 94.5 mg/L for DMAPA and 100.5 mg/L for DEAPA (nominal) .
In conclusion, the inhibition of the degradation activity of activated sludge is not anticipated when 3 -aminopropyldimethylamine is introduced in appropriately low concentrations.
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