Registration Dossier
Registration Dossier
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EC number: 203-505-6 | CAS number: 107-58-4
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental results of test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as- 2. and 3.
- GLP compliance:
- not specified
- Transformation products:
- not specified
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 135 yr
- Type:
- not specified
- Remarks on result:
- other: Acid and based catalyzed hydrolysis rate constant is 12600 & 0.0015 L/mol-sec, respectively.
- pH:
- 8
- Temp.:
- 20 °C
- DT50:
- 14.6 yr
- Type:
- not specified
- Remarks on result:
- other: Acid and based catalyzed hydrolysis rate constant is 12600 & 0.0015 L/mol-sec, respectively.
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 1.5 yr
- Type:
- not specified
- Remarks on result:
- other: Acid and based catalyzed hydrolysis rate constant is 12600 & 0.0015 L/mol-sec, respectively.
- pH:
- 7
- Type:
- not specified
- Remarks on result:
- other: test chemical is not hydrolysable
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
- Executive summary:
Various studies have been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The first study was reviewed from authoritative database (HSDB) in this study the half-life and acid & base catalyzed hydrolysis rate constant of the test chemical was determined at a temperature of 20°C. The acid and based catalyzed hydrolysis rate constant of test chemical was determined to be 12600 & 0.0015 L/mol-sec, respectively with a corresponding half-lives of 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively.
In another study the Electronegative groups on carbon or nitrogen greatly accelerate base catalyzed hydrolysis, but alkyl groups on nitrogen retard both acid and base catalyzed processes and No neutral hydrolysis is evident.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Reference
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Key value for chemical safety assessment
Additional information
Various studies have been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The first study was reviewed from authoritative database (HSDB) in this study the half-life and acid & base catalyzed hydrolysis rate constant of the test chemical was determined at a temperature of 20°C. The acid and based catalyzed hydrolysis rate constant of test chemical was determined to be 12600 & 0.0015 L/mol-sec, respectively with a corresponding half-lives of 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively.
In another study the Electronegative groups on carbon or nitrogen greatly accelerate base catalyzed hydrolysis, but alkyl groups on nitrogen retard both acid and base catalyzed processes and No neutral hydrolysis is evident.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
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