Registration Dossier
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EC number: 203-354-6 | CAS number: 106-02-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EU Method C.3, GLP, key study, validity 2:
72h-ErC10 = 0.42 mg/L;
No ErC50 value can be derived for algae.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 0.42 mg/L
Additional information
Four valid studies are available to assess the toxicity of the substance to aquatic algae.
The first study (Caspers, 1996), assessed as the key study, was performed according to EU Method C.3 with GLP statement on the registered substance. Under the conditions of this test, no ErC50 value can be derived for algae either as insufficient toxicity was observed (72h-ErC50 > 0.47 mg/L, the highest tested concentration) but some effects were observed indicating a potential for toxicity close to the solubility limit, with a 72h-ErC10 value based on growth rate at 0.42 mg/L.
The other studies (Scheerbaum, 2005; Dengler, 2005; Sewell, 1995), assessed as supporting studies, were performed according to OECD Guideline 201 and EU Method C.3 with GLP statement on the read-across substance (EC Number: 422-320-3). This supporting substance is considered adequate for read-across purposes (see Iuclid section 13 for justification). No ErC50 value can be derived for algae because either insufficient toxicity was observed or effects were observed at concentrations greater than the solubility limit. However, some mild effects were observed, especially in the first day of the study although this diminished over the study period, indicating a mild potential for toxicity close to the solubility limit (worst case 72h-ErC10 value at 0.73 mg/L), but it is not clear if these effects are physical or due to actual toxicity of the substance. It is not possible to maintain this concentration under the conditions of an algae study due to degradation and adsorption of the substance during the test. No further algae studies are required.
In conclusion, according to the key study performed on the registered substance, no ErC50 can be derived for algae but the 72h-ErC10 at 0.42 mg/L is used as the key value, greater than the solubility limit of the registered substance.
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