Registration Dossier
Registration Dossier
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EC number: 203-354-6 | CAS number: 106-02-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence approach:
No effects were found up to and including the maximum solubility of the test substance in aqueous test medium. No EC50 can therefore be calculated for acute effects on invertebrates.
Key value for chemical safety assessment
Additional information
Five studies are available, of which two were performed on the registered substance (Harris, 2013; Caspers, 1995) and three were performed on the read-across substance (EC Number: 422-320-3) (Harris, 2013; Stäbler, 2005a; Stäbler, 2005b). This supporting substance is considered adequate for read-across purposes (see Iuclid section 13 for justification).
In these 48 h daphnid acute studies, no effects were found up to and including the maximum solubility of the test substance in aqueous test medium, except the study from Stäbler (2005b) where effects were observed but well above maximum water solubility and quite obviously due to physical adhesion to an oily film at the test vessel surface. No EC50 can therefore be calculated for acute effects on invertebrates. The two studies from Harris were performed under stringent conditions to achieve the maximum aqueous solubility possible using slow-stir techniques and were tested under closed conditions using a semi-static regime.
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