Registration Dossier
Registration Dossier
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EC number: 203-335-2 | CAS number: 105-82-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 26, 2015 to September 21, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out according to internationally recognised guidelines and performed according to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 1,1-dipropoxyethane
- EC Number:
- 203-335-2
- EC Name:
- 1,1-dipropoxyethane
- Cas Number:
- 105-82-8
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 1-(1-propoxyethoxy)propane
- Reference substance name:
- Acetaldehyde dipropyl acetal FAB
- IUPAC Name:
- Acetaldehyde dipropyl acetal FAB
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material (as cited in study report): Acetaldehyde dipropyl acetal FAB
- CAS Number: 105-82-8
- Physical state: colourless liquid
- Lot/batch No.: SC00014817
- Expiration date of the lot/batch: April 07, 2018
Constituent 1
Constituent 2
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.9
- Temp.:
- 35 °C
Any other information on results incl. tables
The determination was performed at 35 °C (temperature of the column) but the value obtained can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Applicant's summary and conclusion
- Conclusions:
- In the conditions of the test, the chromatograms of Acetaldehyde dipropyl acetal FAB show one peak at average retention times of 5.354 minutes, corresponding to a partition coefficent (log value) of 2.9.
Therefore the Partition coefficient n-octanol/water of Acetaldehyde dipropyl acetal FAB, determined using OECD guideline 117 (HPLC), was log Pow 2.9 - Executive summary:
The Partition Coefficient n-octanol/water of Acetaldehyde dipropyl acetal FAB was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117
The result is: Partition coefficient n-octanol/water of Acetaldehyde dipropyl acetal FAB: log Pow = 2.9
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