Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-327-9 | CAS number: 105-75-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
OECD Guideline 203 (Fish, Acute Toxicity Test): LC50, 96h = 0.1 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.1 mg/L
Additional information
The acute toxicity of Di-n-butylfumarate was tested in the fresh water fish, Common Carp (Cyprinus carpio),under semi-static conditions.
Based on the results of the solubility test, the test was carried out up to a maximum of 5 mg/L (concentration equal to the limit of solubility as per OECD 203).
The fish fasted for 24 hours were exposed to a series of nominal concentrations of 0.3125, 0.625, 1.25, 2.5 and 5 mg/L (factor of 2) of
Di-n-butylfumarate along with a negative and vehicle control in reconstituted water and observed for toxic signs and mortality for 96 hours.
At the end of treatment period (96 hours), there was no mortality in the negative control, vehicle control and at 3.125 and 0.625 mg/L. At 1.25, 2.5 and 5 mg/L, the observed mortalities were 30, 80 and 100 %, respectively. Fish were normal with no sub-lethal effects in the negative control, vehicle control and at 0.3125 mg/L. Sub-lethal effects were observed in all other tested concentrations.
The LC50value for Di-n-butylfumarate at 96 hours was 0.10 mg/L based on measured concentrations with fiducial limits at 95 % being 0.07 and 0.14 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
