Registration Dossier
Registration Dossier
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EC number: 203-183-7 | CAS number: 104-19-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 November 2017 to 20 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- EC No 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Batch No.of test material: PFW160141
- Purity: 99.5%
- Expiration date of the lot/batch: 30 December 2018
- Stability under test conditions: Room temperature in the dark - Key result
- Temp.:
- 20 °C
- Remarks on result:
- completely miscible
- Conclusions:
- The test item has been determined to be miscible with water in all proportions (5 to 90% w/w) at 20.0 ± 0.5 °C by visual assessment using a modified flask method.
Reference
The sample concentrations, observations and solution pH are shown in the following table:
Sample |
Concentration (% w/w) |
Observations |
Solution pH |
1 |
5.2 |
Clear colorless single phase solution, no visible test item present, no Tyndall beam. |
11.4 |
2 |
24.8 |
Clear colorless single phase solution, no visible test item present, no Tyndall beam. |
11.4 |
3 |
47.9 |
Slightly discolored, single phase solution, no visible test item present, no Tyndall beam. |
11.5 |
4 |
75.3 |
Slightly discolored, single phase solution, no visible test item present, no Tyndall beam. |
11.5 |
5 |
90.3 |
Slightly discolored, single phase solution, no visible test item present, no Tyndall beam. |
11.5 |
Overall result: Miscible with water in all proportions at 20.0 ± 0.5 °C.
Description of key information
The determination of the water solubility of the test item was carried out by visual assessment, using a modified flask method.
Therefore, a range of sample concentrations ranging from 5 to 90% w/w was prepared for visual assessment. The test item has been determined to be miscible with water in all proportions at 20.0 ± 0.5 °C (K1, Covance, 2019).
Key value for chemical safety assessment
Additional information
The test item is miscible with water in all proportions at 20.0 ± 0.5 °C.
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