Registration Dossier
Registration Dossier
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EC number: 202-969-7 | CAS number: 101-72-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of 4-Hydroxydiphenylamine the main hydrolysis product of IPPD to Daphnia magna was investigated in a static test according to EC No 440/2008, Method C.2 'Acute toxicity for Daphnia' (2008) which is equivalent to OECD Guideline for Testing of Chemicals No. 202 'Daphnia sp., Acute Immobilisation Test (adopted April 13, 2004). After 48 hours of exposure an EC50 of 0.69 mg/L (nominal) was determined (Currenta, 2010).
A second key study performed with the parent substance IPPD (Duslo 2007) resulted in an EC50 of 0.98 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.69 mg/L
Additional information
IPPD hydrolysis rapidly with a half- life of 3.9 hours under conditions relevant for the environment. In this case the REACH guidance document R7 allows the choice of performing the ecotox study either with the parent compound or with the hydrolysis product. In the current case studies for both, parent compound and hydrolysis product are available.
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