Registration Dossier
Registration Dossier
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EC number: 202-874-0 | CAS number: 100-64-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Cyclohexanone oxime was tested for acute daphnia toxicity in a reliable (with restrictions, RL2) study according to DIN 38412 L 11 and equivalent to OECD 202. The validity criteria of the guidelines were fulfilled.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 22 mg/L
Additional information
Cyclohexanone oxime was tested for acute daphnia toxicity in a reliable (with restrictions, RL2) study according to DIN 38412 L 11 and equivalent to OECD 202. The validity criteria of the guidelines were fulfilled. 20 organisms per concentration devided into 4 replicates were tested in 8 concentration groups (10 mg/L to 580 mg/L) and a control. The determined 48 hour effect concentrations (nominal concentrations) for Daphnia magna (according to DIN 38412 L 11 and equivalent to OECD 202) are:
EC50 (48 h) = 22.0 mg/L (95% CI: 20 mg/L - 24 mg/L);
EC0 (48 h) = 10 mg/L EC100 (48 h) = 32 mg/L.
This is supported by a study summary on an acute immobilization test of cyclohexanone oxime to Daphnia magna (study owner: Environment Agency Japan) available from J-Check, an internet resource from National Institute of Technology and Evaluation (NITE) Japan (RL4, as no original study report available). The study was conducted according to OECD 202 and compliant to GLP. The study design was static with analytical verification of test item concentration. 5 concentration groups (300, 167, 92.6, 51.4, 28.6 mg/L) and a control were tested with 20 animals, each, distributed over 4 replicates. The EC50 (48 h; immobilisation) was determined to be 71.7 mg/L (95 % CL 51.4 - 92.6 mg/L).
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