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Diss Factsheets
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EC number: 202-873-5 | CAS number: 100-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Evidence from toxicokinetic and toxicity studies and from human experience indicates that phenylhydrazine is well absorbed by the inhalation, oral, and dermal routes in animals and humans.
Distribution
Once absorbed, phenylhydrazine appears to be rapidly taken up by red blood cells, where it binds readily to haemoglobin. There is little information available on tissue distribution.
Metabolism
Following absorption, phenylhydrazine distributes within the organism. Notably, the substance reacts with carbonyl groups, –C=O, common among biological molecules. It is therefore expected that direct binding to biological molecules would occur. Evidence from a number of studies in vitro and in vivo suggests that phenylhydrazine interacts with haemoglobin and cytochrome P-450 in an oxidation reaction (e.g., Itano et al., 1975; Valenzuela et al., 1977, 1981; Goldberg et al., 1979; Jain & Hochstein, 1979; Jonen et al., 1982; Hill, 1985; Marks, 1985; Di Cola et al., 1988, 1989; Maples et al., 1988). The main phase I reactions are hydroxylation of the aromatic ring to p-hydroxyphenylhydrazine (McIsaac et al., 1958). Following phase I metabolism phase II conjugation reactions with glucuronic acid, and production of phenylhydrazones, by reaction with natural keto acids are likely to increase excretion via urine (low molecular species) and faeces (high molecular weight species)
Excretion
Excretion following a single dose application is primarily via the urine (McIsaac et al., 1958). A significant proportion of a single dose was excreted relatively slowly; 50% of the of phenylhydrazine was excreted within 4 days.
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