Registration Dossier
Registration Dossier
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EC number: 202-784-1 | CAS number: 99-75-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
Increased pre- and postimplantation losses were observed, but the exposure was maternally toxic (Krotov and Chebotar, 1972).
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEC
- 150 mg/m³
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Embryotoxic effects at maternal toxic concentrations
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Embryotoxic effects were oberved only at an exposure concentration, which produced maternal toxicity. Therefore they are considered to be secondary effects to maternal toxicity. The exposure did not produce other developmental effects including teratogenicity. The study is considered to be reliable with respect to effects on offspring. No classification is required as developmental toxicant.
Justification for selection of Effect on developmental toxicity: via inhalation route:
Reliable study with adequate exposure
Justification for classification or non-classification
Based on the available information, no classification is required according to CLP (Regulation (EC) No 1272/2008) and DSD-DPD (Council Directive 67/548/EEC).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
