Registration Dossier
Registration Dossier
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EC number: 202-784-1 | CAS number: 99-75-2
Endpoint summary
Administrative data
Description of key information
Maternal effects of equivocal relevance have been reported after inhalation exposure of rats, but exposure conditions and effects are insufficiently reported.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- There is only information from a not reliable (RL3) study.
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A developmental toxicity study in rats was performed by Krotov and Chetobar (1972). Maternal effects of this inhalation study were not stated, but effects from former examinations at "similar exposure concentrations" were reported to be altered activity of cholinesterase, altered chronaxy, blood proteins and histomorphology (no further details).
This information was regarded to be not reliable (RL3) and no definite conclusions can be drawn.
Justification for classification or non-classification
There is no reliable information with respect to repeated dose toxicity for oral, dermal and inhalation exposure.
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