5-nitro-o-anisidine

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 2.3.

GLP compliance:

no

Test type:

standard acute method

Species:

rat

Strain:

Brown Norway

Sex:

male/female

Route of administration:

oral: unspecified

Vehicle:

not specified

Control animals:

not specified

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 315.143 mg/kg bw

Based on:

test mat.

The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= 0.971

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 2.06

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight.

Executive summary:

The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 315.143 mg/kg bw

Quality of whole database:

The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 2.3.

GLP compliance:

no

Test type:

other: Acute Rodent Inhalation Toxicity Test

Species:

rat

Strain:

other: Wistar;Sprague-Dawley;CnR-CD;Long-Evans

Sex:

not specified

Route of administration:

inhalation

Type of inhalation exposure:

other: Inhalation: Vapor

Vehicle:

not specified

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Control animals:

not specified

Sex:

not specified

Dose descriptor:

LC50

Effect level:

218.23

Based on:

test mat.

Exp. duration:

4 h

The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= 0.347

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.45

Interpretation of results:

not classified

Remarks:

Migrated information

Conclusions:

The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.

Executive summary:

The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LC50

Value:

218.23 mg/m³ air

Quality of whole database:

The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.

Additional information

Acute toxicity oral

The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.

The various weight of evidence studies can be summarised as follows :

Acute toxicity : oral	Sr. No	End point	Species	Effect level
	1	LD50	Rattus norvegicus	2315.143 mg/kg of body weight
	2	LD50	Peromyscus maniculatus	2028.969 mg/kg of body weight
	3	LD50	Rat	2250 mg/kg
	4	LD50	Mouse	1060 mg/kg
	5	LD50	Rabbit	1000 mg/kg
	6	LD50	Rat	704 mg/kg

Acute toxicity inhalation

The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.

Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.

Justification for selection of acute toxicity – inhalation endpoint
The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.