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Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
Deviations:
yes
Remarks:
no data about GLP
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (as cited in study report): m-Nitrotoluene
- Analytical purity: >99%
Test organisms (species):
Cyprinus carpio
Details on test organisms:
Weight: ca. 30 g
Lenght: ca. 10 cm
15-20 fish/level
Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
6 wk
Hardness:
not specified
Test temperature:
25 ± 2 °C
pH:
not specified
Dissolved oxygen:
6-8 mg/L
Details on test conditions:
TEST MEDIUM / WATER PARAMETERS

- Intervals of water quality measurement: twice a week
- Intervals of test medium replacement: 200-800 mL/min

Nominal and measured concentrations:
10; 100 µg/L
Lipid content:
3.5 %
Time point:
end of exposure
Key result
Conc. / dose:
25 other: Conc.in environment / dose: 25 µg/L
Type:
BCF
Value:
0.47 - 8.5
Key result
Conc. / dose:
2.5 other: Conc.in environment / dose: 2.5 µg/L
Type:
BCF
Value:
3 - 12
Remarks on result:
other:
Validity criteria fulfilled:
not specified
Conclusions:
In an experimental study similar to OECD guideline 305C, the BCF in Cyprinus carpio after exposure to 3-nitrotoluene over a period of 6 weeks was determined at two dose levels:

Concentration in environment / dose level : 25 ppb(w/v); BCF values: 0.47 - 8.5

Concentration in environment / dose level : 2.5 ppb(w/v); BCF values: 3 - 12
Executive summary:

MITI, 1992


In an experimental study similar to OECD guideline 305C, the BCF in Cyprinus carpio after exposure to 3-nitrotoluene over a period of 6 weeks was determined at two dose levels:


Concentration in environment / dose level : 25 ppb(w/v); BCF values: 0.47 - 8.5


Concentration in environment / dose level : 2.5 ppb(w/v); BCF values: 3 - 12

Description of key information

For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".


MITI, 1992


In an experimental study similar to OECD guideline 305C, the BCF in Cyprinus carpio after exposure to 3-nitrotoluene over a period of 6 weeks was determined at two dose levels:


Concentration in environment / dose level : 25 ppb(w/v); BCF values: 0.47 - 8.5


Concentration in environment / dose level : 2.5 ppb(w/v); BCF values: 3 - 12

Key value for chemical safety assessment

BCF (aquatic species):
12 dimensionless

Additional information