Registration Dossier
Registration Dossier
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EC number: 202-645-5 | CAS number: 98-17-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: shake flask method.
-Parameters analysed / observed: The concentration of the sample in the water layer was determined, and that in the octanol was obtained by difference. The partition coefficient was calculated from the obtained values. - GLP compliance:
- not specified
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.95
- Temp.:
- 25 °C
- Remarks on result:
- other: No further details specified.
- Conclusions:
- The partition coefficient 1-octanol/water (log Kow) of the test item is 2.95.
- Executive summary:
The determination of the test substance's partition coefficient 1-octanol/water was carried out using the shake-flask method. Only the concentration of the sample in the water layer was determined, and that in the octanol was obtained by difference. Taking into account the solubility of the test substance in water and its solubility in 1-octanol, the partition coefficient was calculated. The partition coefficient 1-octanol/water (log Kow) of the test item is 2.95.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.86
- Remarks on result:
- other: No further details provided.
- Conclusions:
- The partition coefficient 1-octanol/water (log Kow) of the test item is 2.86.
- Executive summary:
The determination of the test substance's partition coefficient 1-octanol/water was carried out using the HPLC method, according to OECD guidelines for testing of chemicals. The partition coefficient 1-octanol/water (log Kow) of the test item is 2.86.
Referenceopen allclose all
Description of key information
Weight of evidence. Based on available data, the test item has a
log Kow = 2.95 (worst case).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.95
- at the temperature of:
- 25 °C
Additional information
Weight of evidence. Based on available data from two available experimental studies, the test item has a log Kow = 2.95 (worst case). In one study, the log Kow was determined using the shake flask method, determining the sample concentration in the water layer and obtaining the concentration in the octanol layer by difference. The resulting logKow was 2.95. In another study, the log Kow was determined by HPLC method according to OECD guidelines, but no further information is available. The resulting log Kow was 2.86. Based on the available data, the test item has a log Kow = 2.95, as a worst case scenario.
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