Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-453-1 | CAS number: 95-80-7
Endpoint summary
Administrative data
Description of key information
Regarding results obtained for the mixed TDA and 2,4-TDA. It is necessary to make distinction between these two susbtances to evaluate the acute
toxicity effects.
Key value for chemical safety assessment
Additional information
For 2,4 -TDA, only 2 studies from same author and performed for acute oral toxicity on rats males and females were validity 2 and chosen as key studies. The LD50 were 136 mg/kg bw for males and 73 mg/kg bw for females.
No data were available for dermal and acute inhalation for 2,4 -TDA.
European Union Risk Assessment Report, 28.05.2008: "A dermal LD50 value of 1200 mg/kg bw was determined for rats using „a standardized method“ with 10 rats per dose (24 hours application with water as vehicle, no further information)."
Justification for classification or non-classification
Classification according to Annex I of the directive 67/548/EEC - 26. on the basis of acute toxicity:
T Toxic, R 20/21 Harmful by inhalation and in contact with skin. R 25 Toxic if swallowed
By CLP, Acute Cat 3, Danger. Toxic if swallowed.
Acute cat 4. Warning. Harmful in contact with skin. Harmful if inhaled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
