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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database and seconday source
Qualifier:
according to guideline
Guideline:
other: Bioaccumulation test of a chemical substance in fish or shellfish provided in the Notice on the Test Method Concerning New Chemical Substances
Principles of method if other than guideline:
To determine bioaccumulation of test chemical
GLP compliance:
not specified
Test organisms (species):
Cyprinus carpio
Details on test organisms:
- Common name: common carp
- Length at study initiation: 8 cm
Route of exposure:
aqueous
Test type:
static
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
6 wk
Nominal and measured concentrations:
1st Concentration area: 1 mg/L,
2nd Concentration area: 0.1 mg/L
Lipid content:
3.7 %
Time point:
start of exposure
Key result
Conc. / dose:
1 mg/L
Type:
BCF
Value:
1.5 L/kg
Basis:
whole body w.w.
Time of plateau:
6 wk
Remarks on result:
other: No other data available
Conc. / dose:
0.1 mg/L
Type:
BCF
Value:
3.8 <= L/kg
Basis:
whole body w.w.
Time of plateau:
6 wk
Remarks on result:
other: No other data available

Bioaccumulation test results

 

2W

3W

4W

6W

1st Concentration

area

Test substance

concentration (mg/L)

0.964

0.955

0.960

0.970

Bioconcentration

factor (L/kg)

2.6

2.0

2.6

1.5

3.2

1.7

2.4

1.8

2nd Concentration

area

Test substance

concentration (mg/L)

0.0956 

0.0950

0.0986

0.101

Bioconcentration

factor (L/kg)

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8

<= 3.8
Validity criteria fulfilled:
not specified
Conclusions:
The Bioaccumulation factor (BCF) for the substance was determined to be at 1.5 L/kg for 1 mg/L and <= 3.8 L/kg for 0.1 mg/L
Executive summary:

Study was conducted to determine the bioaccumulation of test chemical in Cyprinus carpio. After the exposure of test chemical with Cyprinus carpio, it was observed that the chemical is non-bioaccumulative as BCF was deteremined to be 1.5 L/kg for 1 mg/L

Description of key information

The Bioaccumulation factor (BCF) for the substance was determined to be at 1.5 L/kg for 1 mg/L and<= 3.8 L/kg for 0.1 mg/L

 

Key value for chemical safety assessment

Additional information

Following study includes experimental study for the target chemical to observe the bioconcentration of test chemical.

Study (J-check) was conducted to determine the bioaccumulation of test chemical in Cyprinus carpio. After the exposure of test chemical with Cyprinus carpio, it was observed that the chemical is non-bioaccumulative as BCF was deteremined to be at 1.5 L/kg for 1 mg/L and <= 3.8 L/kg for 0.1 mg/L