Registration Dossier
Registration Dossier
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EC number: 202-086-7 | CAS number: 91-64-5
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- other: solutionl
- Details on test material:
- Weigh accurately a certain amount of coumarin to make mother liquor of 1mg/ml with a 20% ethanol solution. It can be diluted to a certain concentration with buffer solution of a specific PH value for use.
Constituent 1
Results and discussion
- Dissociating properties:
- no
Dissociation constantopen allclose all
- No.:
- #1
- pKa:
- 10.06
- Temp.:
- 20 °C
- No.:
- #2
- pKa:
- 10.03
- Temp.:
- 20 °C
- No.:
- #3
- pKa:
- 9.88
- Temp.:
- 20 °C
- No.:
- #4
- pKa:
- 9.44
- Temp.:
- 20 °C
- No.:
- #5
- pKa:
- 10.1
- Temp.:
- 20 °C
Applicant's summary and conclusion
- Conclusions:
- pKa is calculated as 9.9~0.27 according to the formula.
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