Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- HPLC method
- GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: purchased from Aldrich (Castle Hill, Australia) and Fluka (Castle Hill, Australia).
OTHER SPECIFICS:
The standard compounds and terpenoirds were of 95 % purity or greater as determined by gas chromatography (GC) - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.4
- Temp.:
- 37 °C
- pH:
- 7.2
- Details on results:
- Log Pow of 3.4 for L- and DL-Menthol
- Conclusions:
- The partition coefficient of DL-Menthol is 3.4 at 37°C and pH 7.2.
- Executive summary:
The partition coefficient (log Pow) of 3.4 at 37°C and pH 7.2 is determined for DL-Menthol using the HPLC method.
Reference
For the test substance, the capacity factor was calculated and the logKow value was determined with reference to the calibration curve.
Description of key information
The partition coefficient (log Pow) of 3.4 at 37°C and pH 7.2 is determined for DL-Menthol using the HPLC method.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.4
- at the temperature of:
- 37 °C
Additional information
Other literatures report values of 3.23 at 43 °C (Suzuki 1991) and 3.79 and 3.3 (Beilstein 2009) for Menthol, which vary in the same range.
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