Caryophyllene

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 January 2017 to 20 January 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)

Version / remarks:

2006

GLP compliance:

yes (incl. QA statement)

Type of method:

slow-stirring method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

photometric method

Key result

Type:

log Pow

Partition coefficient:

6.23

Temp.:

25 °C

pH:

7

Remarks on result:

other:

Remarks:

Testing was performed without pH adjustment to the mobile phase.

Details on results:

The equilibrium was achieved after 189 hours, with four consecutive sampling times yielding similar log Pow values. The overall mass balance was calculated and recovery values compared to the added total amount of test item ranged from 93 to 94%.

Table 1. Slow-Stirring Test - Results obtained for Log Pow

Stirring time (hours	Measured concentration in n-octanol (mg/L)			Measured concentration in water (mg/L)			Log Pow
	Test 1	Test 2	Test 3	Test 1	Test 2	Test 3	Test 1	Test 2	Test 3
189	18688	19449	19547	0.0076	0.0155	0.0084	6.39	6.10	6.37
206	19087	19292	19483	0.0091	0.0170	0.0095	6.32	6.06	6.31
211	19039	19273	19941	0.0099	0.0173	0.0102	6.28	6.05	6.29
216	18574	18787	18884	0.0095	0.0180	0.0095	6.29	6.02	6.30
Mean values							6.32	6.06	6.32
Overall mean							6.23 ± 0.15 (2.4% RSD)

The tabulated values of the samples represent rounded results obtained by calculation using the exact data.

Conclusions:

The log partition coefficient of the test material was determined to be 6.23 ± 0.15 at 25°C.

Executive summary:

The partition coefficient (n-octanol/water) was tested according to OECD TG 123 (2006). This study is assigned a reliability of 1 (reliable without restrictions) as it followed an accepted guideline and was GLP-compliant. The log partition coefficient of the test material was determined to be 6.23 ± 0.15 at 25°C.

Description of key information

The log partition coefficient of the test material was determined to be 6.23 ± 0.15 at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):

6.23

at the temperature of:

25 °C

Additional information

The partition coefficient (n-octanol/water) was tested according to OECD TG 123 (2017). This study is assigned a reliability of 1 (reliable without restrictions) as it followed an accepted guideline and was GLP-compliant. The log partition coefficient of the test material was determined to be 6.23 ± 0.15 at 25°C by the slow-stirring method.