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EC number: 201-741-4 | CAS number: 87-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015.03.09-2015.03.11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- No verification of test concentrations
- Principles of method if other than guideline:
- 20 daphnids devided in 4 groups were exposed to the test item for 48 hours. Immobility was monitored every 24 hours and an EC50 and a NOEC value determined.
As a negative control standard freshwater (ISO6341) was applied.
Daphnids were not feed during the study - GLP compliance:
- no
- Remarks:
- The kit from Microbiotests has been extensivley used at our laboratory and database at our laboratory shows that results obtained with the kit are reliable and valid to be used for assesment of acute toxicity towards daphnids.
Test material
- Reference substance name:
- 5-hydroxyiminobarbituric acid
- EC Number:
- 201-741-4
- EC Name:
- 5-hydroxyiminobarbituric acid
- Cas Number:
- 87-39-8
- Molecular formula:
- C4H3N3O4
- IUPAC Name:
- 5-(hydroxyimino)-1,3-diazinane-2,4,6-trione
- Test material form:
- solid: particulate/powder
- Details on test material:
- Lot/batch No.: 201713807
Constituent 1
- Specific details on test material used for the study:
- Batch number: BFB083-172
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- no sampling
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test organisms were recieved from Ghent University in Belgium, Laboratory for Biological Research in Aquatic Pollution. DAPHTOXKIT FTM Magna from Microbiotests, containing Ephippia. Daphnids were < 24 h old at the initiation of the test.
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- not included
Test conditions
- Hardness:
- NA
- Test temperature:
- 20-22 degrees celcius
- pH:
- 6.95
- Dissolved oxygen:
- Test media was saturated with oxygen before the test was initiated
- Salinity:
- NA
- Conductivity:
- NA
- Nominal and measured concentrations:
- Nominal: 6.25, 12.5; 25; 50; 100 mg/L
- Reference substance (positive control):
- no
- Remarks:
- every 6 month a study with potassiumdichromate is conducted
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 10.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 10.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Endpoint exammined: Immobility
- Reported statistics and error estimates:
- Software applied for calculation of the EC50 and NOEC value: ToxRAT
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A NOEC and an EC50 of 6.3 mg/L and 10.8 mg/L determined after 24 hours.
After 48 hours the corresponding values were 6.3 mg/L and 10.6 mg/L. - Executive summary:
The acute toxicity of the test item Violuric acid towards invertebrate (Daphnia magna) was tested according to the principles described in the OECD Guideline no. 202.
20 daphnids/concentration devided in 4 groups were exposed for 48 hours and immobility assessed after 24 and 48 hours. Daphnids were not feed during the study and no analytical verifications of the test concentrations were performed.
A NOEC and an EC50 of 6.3 mg/L and 10.8 mg/L determined after 24 hours. After 48 hours the corresponding values were 6.3 mg/L and 10.6 mg/L.
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