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Diss Factsheets
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EC number: 201-741-4 | CAS number: 87-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-06-07 to 2018-08-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1997
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -1.2
- Temp.:
- 25 °C
- pH:
- 2
- Conclusions:
- Violuric acid was determined to have a logPow value of -1.2 at 25°C.
- Executive summary:
The octanol-water partition coefficient of violuric acid was determined according to OECD test guideline no. 107: 'Partition Coefficient (n-octanol/water): Shake Flask Method'.
Violuric acid is an ionized substance and therefore, the test was performed at pH 2.0 where test the test substance is in undissociated form to ensure worst case scenario for parttition into the octanol phase.
Volume ratios for 1 -octanol and water phase were selected according to the OECD guidance and the 1 -octanol: water ratios were as follows: Condition 1) 1:2, condition 2) 1:1 and condition 3) 2:1. Duplicate tests were performed for each test condition. The 1 -octanol phase were prior to the test saturated with the buffer solution (10 mmol/L potassium dihydrogen phosphate) and vice versa. The test item was dissolved in the buffer solutiuon saturated with 1 -octanol and measured with HPLC. After the end of the test test substance concentration in each phase was measured by HPLC.
The range of logPow value was -1,28 to -1.14 and were within the range of +/- 0.3 units and the material balance was > 98%. The test was thgus considered reliable.
In conclusion, the logPow of VA is -1.2 at 25°C.
Reference
Description of key information
The octanol-water partition coefficient was determined according to OECD TG 107: Shake Flask Method and violuric acid was found to have a logPow value of -1.2 at 25°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.2
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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