Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-696-0 | CAS number: 86-74-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation / corrosion
In a primary skin irritation test with 6 rabbits, minimal irritation effects (score 1 erythema and edema) were observed on the intact skin of three animals after 24h application of 5 mL of a 10% suspension of carbazole in 0.5% carboxymethyl cellulose (500 mg test substance). Effects subsided within 48 h (HRC 1979a). The mean score for erythema and edema was 0.167 for the reading immediately after removal of patch. In a well-performed non-standard test, carbozole did not induce photo-irritation on the skin of guinea pig in the absence and presence of UV-light (Kochevar et al. 1982).
Eye irritation
In a limited primary eye irritation test with 6 rabbits, carbazole proved to be not irritating after instillation of ca. 10 mg test substance suspended in 100 µL of 0.5 % carboxymethyl cellulose. Eye reactions were minor (only conjuctivae redness and chemosis, score 1 to 2), but redness had not completely disappeared at day 7, the latest observation time (HRC 1979b). Anthracene, the structure-analogous compound, failed to elicit eye irritation in a valid standard study (HRC 1979c), thus supporting the finding for carbazole.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
