6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is unlikely to cross biological membranes, hence indicating that aquatic toxicity is unlikely to occur

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: Currenta internal SOP 00190 Version 3

Version / remarks:

This SOP is based on the Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of the physical-chemical properties, A.6, “Water solubility” and to the OECD guideline for testing of chemicals No: 105 “Water solubility“.

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: Currenta internal SOP 00178 Version 3 for the determination of the pH-value

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

0.071 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 6.3 - <= 7.5

Remarks on result:

other: mean value of both columns

Conclusions:

The GLP study was performed according to OPPTS 830.7840 without deviations and therefore reliability of Klimisch 1 has been assigned. The water solubility has been determined to be 0.071 mg/L (insoluble) at 20 °C and pH 6.3 - 7.5.

Executive summary:

The water solubility of the test item pyridon was determined with the column elution method at 20 °C according to OPPTS 830.7840. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis. The water solubility of the test item is stated as: 0.071 mg/L. Difference between both columns: 17 %; the validity criterion (mean of both determinations should not differ by more than 30 %) was met. The substance is insoluble in water.