Registration Dossier
Registration Dossier
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EC number: 201-381-8 | CAS number: 81-85-6
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Currenta internal SOP 00190 Version 3
- Version / remarks:
- This SOP is based on the Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of the physical-chemical properties, A.6, “Water solubility” and to the OECD guideline for testing of chemicals No: 105 “Water solubility“.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Currenta internal SOP 00178 Version 3 for the determination of the pH-value
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- 6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione
- EC Number:
- 201-381-8
- EC Name:
- 6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione
- Cas Number:
- 81-85-6
- Molecular formula:
- C17H10BrNO2
- IUPAC Name:
- 6-bromo-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.071 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 6.3 - <= 7.5
- Remarks on result:
- other: mean value of both columns
Applicant's summary and conclusion
- Conclusions:
- The GLP study was performed according to OPPTS 830.7840 without deviations and therefore reliability of Klimisch 1 has been assigned. The water solubility has been determined to be 0.071 mg/L (insoluble) at 20 °C and pH 6.3 - 7.5.
- Executive summary:
The water solubility of the test item pyridon was determined with the column elution method at 20 °C according to OPPTS 830.7840. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis. The water solubility of the test item is stated as: 0.071 mg/L. Difference between both columns: 17 %; the validity criterion (mean of both determinations should not differ by more than 30 %) was met. The substance is insoluble in water.
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