Registration Dossier
Registration Dossier
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EC number: 200-927-2 | CAS number: 76-03-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Weight of evidence: Experimental results on the substance trichloroacetic acid and read-across from experimental data on the analogue sodium trichloroacetate.
Trichloroacetic acid was evaluated with the Guinea Pig Maximization Test (GPMT). None of the test animal showed any irritating or sensitising symptoms. The test substance resulted to be not sensitising. Results from a non-guideline compliant test (The Mouse Ear Swelling Test, MEST) support the negative results obtained with the Guinea Pig Maximization Test (GPMT) since none of the animals showed any response. The positive controls included in both experiments showed a 100% response.
Based on company data on the analogue sodium trichloroacetate (OECD 406), which is considered to be not sensitising, and applying the read-across approach, the substance trichloroacetic acid is also considered to be not sensitising.
Migrated from Short description of key information:
Weight of evidence: Experimental results on the substance trichloroacetic acid and read-across from experimental data on the analogue sodium trichloroacetate.
Trichloroacetic acid was evaluated with the Guinea Pig Maximization Test (GPMT). None of the test animals showed any irritating or sensitising symptoms. The test substance resulted to be not sensitising. Results from a non-guideline compliant test (The Mouse Ear Swelling Test, MEST) support the negative results obtained with the Guinea Pig Maximization Test (GPMT) since none of the animals showed any response.
Based on company data on the analogue sodium trichloroacetate (OECD 406), which is considered to be not sensitising, and applying the read-across approach, the substance trichloroacetic acid is also considered to be not sensitising.
Justification for classification or non-classification
Based on the experimental results, the substance is not classified as skin sensitiser.
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