Registration Dossier
Registration Dossier
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EC number: 200-889-7 | CAS number: 75-65-0
Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Information on neurological effects is available from repeated dose toxicity studies summarized elsewhere in this document. In addition, information on developmental neurotoxicity is available from a non-guideline study in rats (Grant and Samson (1982). In this study, pups were dosed directly with tertiary butyl alcohol on postnatal days 4-7 of lactation, which in contrast to the OECD guideline No 426 (developmental neurotoxicity study), where pups are exposed via lactation. Confidence in the findings of the study is reduced by the large number of deaths (possible due to dosing) and variable dosage given to the only dose group (between 600- 2690 mg/kg bw/day). Overall, this study provides no information on the potential developmental neurotoxicity of tertiary butyl alcohol.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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