Registration Dossier
Registration Dossier
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EC number: 200-839-4 | CAS number: 75-10-5
Carcinogenicity
Administrative data
Description of key information
No carcinogenicity study is available. Difluoromethane is not classified for mutagenicity and there is no evidence from the 13 week repeated dose toxicity study that difluoromethane is able to induce hyperplasia and/or pre-neoplastic lesions. In addition, no target organ has been identified. In conclusion, there is no indication of a carcinogenic potential for HFC-32.
Key value for chemical safety assessment
Justification for classification or non-classification
Since difluoromethane is not classified for mutagenicity and there is no evidence from the 13 week repeated dose toxicity study that difluoromethane is able to induce hyperplasia and/or pre-neoplastic lesions, the substance is currently considered non-carcinogenic. Classification according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2000 is not warranted.
Additional information
No carcinogenicity study is available. However, since difluoromethane is not classified for mutagenicity and there is no evidence from the 13 week repeated dose toxicity study that difluoromethane is able to induce hyperplasia and/or pre-neoplastic lesions there is no concern for carcinogenic properties.
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