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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Up to 2021
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Episuite and the BCFBAFWin models are well documented and commonly used QSARs for predicting the bioaccumulation potential of chemicals. Substances within LOA fall within the applicability domain of these models and they have been recommended by ECHA in the Information Requirement Guidelines.
Qualifier:
no guideline required
Principles of method if other than guideline:
The BCFBAF program estimates BCF of an organic compound using the compound's log octanol-water partition coefficient (Kow). The measured BCF values used in the model regressions were selected from a quality reviewed BCF database (Arnot and Gobas, 2006). BCFBAF includes estimation of the Biotransformation Rate (kM) in fish and estimation of Bioaccumulation Factor (BAF) by the Arnot-Gobas method (Arnot and Gobas, 2003).
Specific details on test material used for the study:
N/A
Details on sampling:
N/A
Details on preparation of test solutions, spiked fish food or sediment:
N/A
Details on test organisms:
N/A
Hardness:
N/A
Test temperature:
N/A
pH:
N/A
Dissolved oxygen:
N/A
TOC:
N/A
Salinity:
N/A
Conductivity:
N/A
Details on test conditions:
N/A
Nominal and measured concentrations:
N/A
Details on estimation of bioconcentration:
N/A
Key result
Type:
BCF
Value:
2.586 L/kg
Basis:
whole body w.w.
Calculation basis:
other: Regression based estimation
Remarks on result:
other: Result from QSAR
Key result
Type:
BCF
Value:
2.087 L/kg
Basis:
whole body w.w.
Calculation basis:
other: BCF Arno-Gobas method (upper trophic)
Remarks on result:
other: Result from QSAR
Details on kinetic parameters:
N/A
Metabolites:
N/A
Results with reference substance (positive control):
N/A
Details on results:
N/A
Reported statistics:
N/A

N/A

Validity criteria fulfilled:
yes
Conclusions:
The estimated BCF based on the Arnot-Gobas method (upper trophic) for this substance is 2.087 L/kg. Since the value reported is extremely low, there was no lipid correction applied.
Executive summary:

The Bioconcentration Fator for this substance has been estimated using the EPISUITE program and based on methodologies developed by Arnot-Gobas et al. (2006). The estimated BCF based on the Arnot-Gobas method (upper trophic) for this substance is 2.087 L/kg. Since the value reported is extremely low, there was no lipid correction applied.

Description of key information

The Bioconcentration Factor for this substance has been estimated using the EPISUITE program and based on the regression method. The estimated BCF based on the regression method (upper trophic) for this substance is 2.586 L/kg.

Key value for chemical safety assessment

BCF (aquatic species):
2.586 L/kg ww

Additional information

The estimated BCF based on the regression method (upper trophic) for this substance is 2.586 L/kg.