Hydroxyprogesterone

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

not specified

GLP compliance:

no

Type of method:

effusion method: Knudsen cell

Key result

Temp.:

25 °C

Vapour pressure:

< 0.001 Pa

Remarks on result:

other: estimation

Conclusions:

The vapor pressure of Hydroxyprogesterone is estimated to < 0.001 Pa at 25 °C.

Executive summary:

Since simplified experimental conditions are also acceptable within the scope of this project, Hydroxyprogesterone was mixed with four other compounds. From all five test substances low or very low vapor pressures, based on the study directors experience, were expected. For this reason the experiments consisted in the measurement of the evaporation rate of the mixture from a Knudsen cell a 25 °C. Since the evaporation rate of the mixture was below the value derived from the lower limit of the vapor pressure range recommended for the use of a vapor pressure balance (10^-3 Pa, EC Testing Guideline A.4) it can be assumed that the vapor pressure of the mixture is lower than 10^-3 Pa.

Considering this fact, the vapor pressure of the single compounds in the mixture has also to be lower than 10^-3 Pa. Therefore, the vapor pressure of Hydroxyprogesterone can be estimated to be < 0.001 Pa at 25°C.

Description of key information

The vapor pressure is estimated to be lower than 0.001 Pa at 25°C.

Key value for chemical safety assessment

Vapour pressure:

0.001 Pa

at the temperature of:

25 °C