Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

First-aid measures

Consult a physician. Show this safety data sheet to the doctor in attendance.
If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician.
In case of skin contact wash off with soap and plenty of water. Consult a physician.
In case of eye contact rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed nNever give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Fire-fighting measures

Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.

Accidental release measures

Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
Evacuate personnel to safe areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
Methods for cleaning up
Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.

Handling and storage

The substance is an intermediate used for a chemical process only to produce an other pharmaceutical intermediate.
In the plant the charge of Thyoacetamide is performed by charging box (that is collected with the GL reactor used for the reaction involved Thyoacetamide) enclosed in a charging room that is collect to the aspiration by fan. The bags contents in the kraft drums are charged into the box and the powder is charge into the reactor by a pneumatic system. The exhausts bags are treat by immersion in a recipient that contents a water solution of sodium hydroxide and then the bags are sent to the thermic destroy at the plant’s burner.
The plant is equipped with a recipient to collect all the sewers in order to sent it to the biological plant.
The vents of all reactors of the plant are flow thought adapted scrubber and then all the vents are collected in a common pipe line to flow the gases to the burner.
The sampling of the substance is performed in warehouse using situable laminar flow hood.
The analytical tests are performed at the QC laboratory handling the raw material in laminar flow hoods.
During the chemical process the aqueous solutions (that may be containing trace of Thyoacetamide) are sent to the thermic destroy at the burner using pipe line.
At the end of the production campaign every apparatus used is clean washing with adapted solvents.
The criteria adopted in FIS to assure that the apparatus is clean are: visual clean, residue and swab test (only for validation).
There is an internal procedure that established the criteria for the cleaning of the apparatus.
There is an internal procedure that established the maintenance activities for every machine of the plant.

Transport information

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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

During the process workers follow the internal procedure and wear appropriate PPE.
Only trained and authorised personnel handle the substance. The workers are provided with training and with a "safety sheet" for each substance they use; this sheet contains the procedures during the normal handling and during the malfunctioning of the process and in accidental situations with the actions to be taken in order to safeguard themself and other workers at the workplace. Access to all safety data sheet is provided for all workers.

Stability and reactivity

Stable under recommended storage conditions.
Materials to avoid: Strong oxidizing agents, Strong acids, Strong bases
Hazardous decomposition products: Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx),
Sulphur oxides

Disposal considerations

Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal
service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a
chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging: dispose of as unused product.