Sodium salicylate

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from computational model developed by USEPA.

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Estimation of 96 hr EC50 value of test chemical by modelling Database - ECOSAR v.1.11. The ECOSAR Class Program is a computerized version of the ECOSAR analysis procedures as currently practiced by the Office of Pollution Prevention and Toxics (OPPT). It has been developed within the regulatory constraints of the Toxic Substances Control Act (TSCA). It is a pragmatic approach to SAR. The structure-activity relationships (SARs) presented in this program are used to predict the aquatic toxicity of ch
emicals based on their similarity of structure to chemicals for which the aquatic toxicity has been previously measured. Most SAR calculations in the ECOSAR Class Program are based upon the octanol/water partition coefficient (Kow). Various surfactant SAR calculations are based upon the average length of carbon chains or the number of ethoxylate units

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Details on test organisms:

Common name: water flea

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

21 d

Reference substance (positive control):

not specified

Key result

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

4.126 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

growth

Remarks on result:

other: not toxic

Validity criteria fulfilled:

not specified

Conclusions:

Based on the prediction done using the EPI Suite ECOSAR version 1.11, the long term toxicity on daphnia was predicted for test chemical. On the basis of effects observed in a static freshwater system, the effect concentration NOEC value for the substance is estimated to be 4.126 mg/l for Species for 21 days duration.

Executive summary:

Based on the prediction done using the EPI Suite ECOSAR version 1.11, the long term toxicity on daphnia was predicted for test chemical. On the basis of effects observed in a static freshwater system, the effect concentration NOEC value for the substance is estimated to be 4.126 mg/l for daphnia species for 21 days duration. Based on this value, and the test chemical is readily biodegradable it can be concluded that the test substance is considered as non-toxic  to daphnia magna at environmentally relevant concentrations and can be considered as "not classified"  as per the CLP classification criteria.

Description of key information

Based on the prediction done using theEPI Suite ECOSAR version 1.11, the long term toxicity to aquatic invertibrates was predicted for test substance. On the basis of effects observed in a static freshwater system, the effect concentration NOEC value for the substance is estimated to be 4.126 mg/l for Species for 21 days duration.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

4.126 mg/L

Additional information

Based on the prediction done using the EPI Suite ECOSAR version 1.11, the long term toxicity on daphnia was predicted for test chemical. On the basis of effects observed in a static freshwater system, the effect concentration NOEC value for the substance is estimated to be 4.126 mg/l for daphnia species for 21 days duration. Based on this value, and the test chemical is readily biodegradable it can be concluded that the test substance is considered as non-toxic  to daphnia magna at environmentally relevant concentrations and can be considered as "not classified"  as per the CLP classification criteria.