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Annex III inventory

Annex III inventory

ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.

The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.

The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.

Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.

Dibenzofuran

EC / List no.: 205-071-3 CAS no.: 132-64-9
Information source
# Suspected bioaccumulative: Bioaccumulation Canada database in the Toolbox reports at least one value above the B threshold of 2,000 L/Kg (3.3 log units); Bioaccumulation fish CEFIC LRI database in the Toolbox reports at least one value above the B threshold of 2,000 L/Kg (3.3 log units); Bioconcentration NITE database in the Toolbox reports at least one value above the B threshold of 2,000 L/Kg (3.3 log units) # Suspected carcinogen: The Toolbox profiler 'Carcinogenicity (genotox and nongenotox) alerts by ISS' gives an alert for carcinogenicity; ISS Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (moderate reliability) # Suspected hazardous to the aquatic environment: EPA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 1.68 mg/L (EXPERIMENTAL value); Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 1.8 mg/L (EXPERIMENTAL value); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is 'Toxic-2 (between 1 and 10 mg/l) (EXPERIMENTAL value)'; Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 1.84 mg/L (EXPERIMENTAL value);The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of 1.37 mg/L # Suspected mutagen: The Toolbox profiler 'in vitro mutagenicity (Ames test) alerts by ISS' gives an alert for mutagenicity # Suspected persistent in the environment: Ready biodegradability model (IRFMN) in VEGA (Q)SAR platform predicts that the chemical is NON Readily Biodegradable (EXPERIMENTAL value); Biodegradation NITE database in the Toolbox contains at least one experimental data from 28 days ready biodegradability test (OECD TG 301C or 301D) reporting a value lower than 60%;The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable

Download the full Annex III Inventory

You can download the full Annex III inventory as XLS format.

Download Annex III Inventory

 

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