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Annex III inventory

Annex III inventory

ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.

The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.

The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.

Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.

Malathion

EC / List no.: 204-497-7 CAS no.: 121-75-5
Information source
# Harmonised classification for acute toxicity: The substance is listed in Annex VI of CLP as: Acute Tox. 4 # Harmonised classification for aquatic toxicity: The substance is listed in Annex VI of CLP as: Aquatic Acute 1; The substance is listed in Annex VI of CLP as: Aquatic Chronic 1 # Harmonised classification for skin sensitisation: The substance is listed in Annex VI of CLP as: Skin Sens. 1 # Suspected carcinogen: IARC monographs classified the substance as carcinogenic or probably/possibly carcinogenic # Suspected hazardous to the aquatic environment: DEMETRA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 0 mg/L (EXPERIMENTAL value); EPA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 0.0173 mg/L (EXPERIMENTAL value); Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 12.52 mg/L (EXPERIMENTAL value); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is 'Toxic-3 (between 10 and 100 mg/l) (EXPERIMENTAL value)'; Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 14.05 mg/L (EXPERIMENTAL value);The Danish QSAR database contains information indicating that the substance has a 96h LC50 to fish of 1.39 mg/L; The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of <1 mg/L; The Danish QSAR database contains information indicating that the substance has a 96h EC50 to green algae of 14.99 mg/L # Suspected mutagen: The Toolbox profiler 'DNA alerts for AMES, MN and CA by OASIS v.1.3' gives an alert for mutagenicity; In vivo micronucleus test outcome positive according to ISSMIC # Suspected persistent in the environment: Ready biodegradability model (IRFMN) in VEGA (Q)SAR platform predicts that the chemical is NON Readily Biodegradable (EXPERIMENTAL value); Biodegradation NITE database in the Toolbox contains at least one experimental data from 28 days ready biodegradability test (OECD TG 301C or 301D) reporting a value lower than 60% # Suspected skin sensitiser: The Toolbox profiler 'Protein binding alerts for skin sensitization by OASIS v1.3' gives an alert for skin sensitisation # Suspected toxic for reproduction: Developmental/Reproductive Toxicity library (PG) in VEGA (Q)SAR platform predicts that the chemical is Toxicant (moderate reliability)

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You can download the full Annex III inventory as XLS format.

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