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Annex III inventory

Annex III inventory

ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.

The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.

The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.

Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.

Download the full Annex III Inventory

You can download the full Annex III inventory as XLS format.

Download Annex III Inventory

 

Azobenzene

EC / List no.: 203-102-5 CAS no.: 103-33-3
Information source
# Suspected acutely toxic via the oral route: The Danish QSAR database contains information indicating that the substance is predicted as toxic via the oral route. # Harmonised classification for acute toxicity: The substance has the following harmonised classification in Annex VI of CLP: Acute Tox. 4 # Harmonised classification for aquatic toxicity: The substance has the following harmonised classification in Annex VI of CLP: Aquatic Acute 1; The substance has the following harmonised classification in Annex VI of CLP: Aquatic Chronic 1 # Harmonised classification for carcinogenicity: The substance has the following harmonised classification in Annex VI of CLP: Carc. 1B # Harmonised classification for mutagenicity: The substance has the following harmonised classification in Annex VI of CLP: Muta. 2 # Harmonised classification for specific target organ toxicity: The substance has the following harmonised classification in Annex VI of CLP: STOT RE 2 # Suspected carcinogen: The Toolbox profiler 'Carcinogenicity (genotox and nongenotox) alerts by ISS' gives an alert for carcinogenicity; CAESAR Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); ISS Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); Recommended for C category 1A or 1B by IMAP; carcinogen according to ISSCAN # Suspected hazardous to the aquatic environment: EPA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 6.25 mg/L (moderate reliability); Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 0.8979 mg/L (moderate reliability); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is 'Toxic-3 (between 10 and 100 mg/l) (moderate reliability)';The Danish QSAR database contains information indicating that the substance has a 96h LC50 to fish of 1.9 mg/L; The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of 1.31 mg/L; The Danish QSAR database contains information indicating that the substance has a 96h EC50 to green algae of 2.19 mg/L # Suspected mutagen: The Toolbox profiler 'in vitro mutagenicity (Ames test) alerts by ISS' gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); ISS Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); KNN Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); Recommended for M category 2 by IMAP; mutagen according to ISSSTY # Suspected persistent in the environment: Ready biodegradability model (IRFMN) in VEGA (Q)SAR platform predicts that the chemical is Possible NON Readily Biodegradable (good reliability);The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected to meet STOT RE classification: Recommended for STOT RE 2 by IMAP

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