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Annex III inventory

Annex III inventory

ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.

The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.

The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.

Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.

Phenanthrene

EC / List no.: 201-581-5 CAS no.: 85-01-8
Information source
# Suspected bioaccumulative: KNN BCF model in VEGA (Q)SAR platform predicts a BCF of 3.312 log(L/kg) (EXPERIMENTAL value); Meylan BCF model in VEGA (Q)SAR platform predicts a BCF of 3.4 log(L/kg) (EXPERIMENTAL value); Bioaccumulation Canada database in the Toolbox reports at least one value above the B threshold of 2,000 L/Kg (3.3 log units) # Suspected carcinogen: The Toolbox profiler 'Carcinogenicity (genotox and nongenotox) alerts by ISS' gives an alert for carcinogenicity # Suspected hazardous to the aquatic environment: DEMETRA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 0.0972 mg/L (good reliability); EPA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 0.776 mg/L (EXPERIMENTAL value); Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 3.14 mg/L (moderate reliability); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is 'Toxic-2 (between 1 and 10 mg/l) (good reliability)'; Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 1.4 mg/L (EXPERIMENTAL value);The Danish QSAR database contains information indicating that the substance has a 96h LC50 to fish of 1.15 mg/L; The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of <1 mg/L # Suspected mutagen: The Toolbox profiler 'DNA alerts for AMES, MN and CA by OASIS v.1.3' gives an alert for mutagenicity; The Toolbox profiler 'in vitro mutagenicity (Ames test) alerts by ISS' gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); ISS Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (moderate reliability); KNN Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (moderate reliability); SARPY Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value) # Suspected persistent in the environment: Ready biodegradability model (IRFMN) in VEGA (Q)SAR platform predicts that the chemical is Possible NON Readily Biodegradable (moderate reliability); Biodegradation NITE database in the Toolbox contains at least one experimental data from 28 days ready biodegradability test (OECD TG 301C or 301D) reporting a value lower than 60%;The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected skin sensitiser: CAESAR skin sensitisation model in VEGA (Q)SAR platform predicts that the chemical is Sensitizer (good reliability)

Download the full Annex III Inventory

You can download the full Annex III inventory as XLS format.

Download Annex III Inventory

 

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