Carbonic acid, 4-nitrophenyl 5-thiazolylmethyl ester, hydrochloride (1:1)

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 February - 25 August 1995

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study compiled in accordance with GLP. Study material is well characterised.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1995

Report date:

1995

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Deviations:

no

Principles of method if other than guideline:

Determined using a Coulter Counter in accordance with the OECD Guideline 110 Method A Particle Size Distribution. The particle sized was visually determined using a microscope. Orifice tubes were calibrated before and after testing against a Latex standard. A particle size distribution for the spherical diameter of particles was produced by overlapping the average of three tubes digitally using Coulter software. A graph was plotted of Spherical Diameter Vs Percentage Volume over the working range of 700 nm (0.7 microns) to 400 microns. Percentage Volume indicates how many particles within the sample are of a certain size.

GLP compliance:

yes

Type of distribution:

counted distribution

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

414-490-2

EC Name:

-

Cas Number:

154212-59-6

Molecular formula:

C11H9ClN2O5S

IUPAC Name:

4-nitrophenyl (1,3-thiazol-5-yl)methyl carbonate hydrochloride

Results and discussion

Particle size

Percentile:

D50

Mean:

> 2 - < 153 µm

Remarks on result:

other: 95.7% within this range. There were no particles measured with a size greater than 153.0 microns. By volume, it’s estimated that 26.0% of the particles have an aerodynamic diameter of less than 10.0 um, but no less than 2.0 microns. (migrated from fields

Any other information on results incl. tables

Particle Size Distribution:
<= 2.036 microns       5.32%

<= 10.15 microns       29.68 %

2.036-152.9 microns    94.68%

Applicant's summary and conclusion

Conclusions:

The results showed that 5.3% of all particles had a spherical diameter of between 700 and 2036 nm (0.7 - 2.0 micron), with the remaining 95.7% of the distribution having a particle size above this figure, and up to 153 microns.