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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
03 june 2003 - 06 june 2003
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in 2003 according to Method A8 of the Commission Directive 92/69/EEC and in accordance with GLP. Study material is well characterized.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
Commission Directive 92/69/EEC, A8 (shake-flask method).
Deviations:
no
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Remarks:
with HPLC analysis
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
445-910-2
EC Name:
-
Cas Number:
1388152-30-4
Molecular formula:
Hill formula: C24 H32 N2 O7 Si CAS formula: C15 H20 O3 Si . C9 H12 N2 O4
IUPAC Name:
(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
-0.311
Temp.:
21.5 °C
pH:
>= 7.4 - <= 7.5
Type:
log Pow
Partition coefficient:
-0.112
Temp.:
21.5 °C
pH:
>= 7.4 - <= 7.5
Details on results:
As the substance has two component elements (acid and amine), the partiition coefficient of both are given.

Any other information on results incl. tables

The log Pow of the two individual components was determined
as follows:


Acid component: Log Pow = -0.311


Amine component: Log Pow = -0.211


Test was conducted at pH 7, which was considered to be the
most environmentally relevant pH. At this pH the substance
is partially ionised.

Applicant's summary and conclusion

Conclusions:
The measured partition coefficient for both element of the substance are well below the threshold value (3) which would indicate a potiential to bioaccumulate.
Executive summary:

As Substances having a log10 Pow of greater than 3 are regarded as having the potential to bioaccumualate in the environment, this study has shown that this substance would not be expected to pose a bioaccumulation risk.