Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
A radiolabelled study of the metabolism of DEGDB in the rat by oral gavage demonstrated that DEGDB does not have a tendency to bioaccumulate.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

In a metabolism study conducted to OECD guideline 417, virtually all of single oral doses of 50 and 750 mg/kg of [ring-U-14C-phenyl] DEGDB administered to Sprague-Dawley CD rats were absorbed metabolised and excreted in the urine within 24 hours of administration. DEGDB was metabolised via hydrolysis of the ester bonds to benzoic acid; this free acid was then conjugated with either glycine (major pathway) or glucuronic acid (minor pathway) prior to excretion.