Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 259-097-5 | CAS number: 54322-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The skin sensitization potential of Methanetrisulfonic acid (CAS no: 54322-33-7) was estimated using OECD QSAR toolbox version 3.3 with log Pow as the primary descriptor. The Methanetrisulfonic acid (CAS no: 54322-33-7) was estimated to be not sensitizing to the female CBA Mice. Based on the estimated result Methanetrisulfonic acid (CAS no: 54322-33-7) failed to induce skin sanitization effects and hence is considered to be not sensitizing to female CBA Mice.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox version 3.3 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- No data available
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- No data available
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Parameter:
- SI
- Value:
- 1.5
- Remarks on result:
- other: no senitization was observed.
- Cellular proliferation data / Observations:
- No senitization was observed.
- Interpretation of results:
- other: not sensitising
- Conclusions:
- The Methanetrisulfonic acid (CAS no: 54322-33-7)was estimated to be not sensitizing to the female CBA Mice . Based on the estimated result Methanetrisulfonic acid (CAS no: 54322-33-7) failed to induce skin sanitization effects and hence is considered to be not sensitizing to female CBA Mice.
- Executive summary:
The skin sensitization potential of Methanetrisulfonic acid (CAS no: 54322-33-7) was estimated using OECD QSAR toolbox version 3.3 with log Pow as the primary descriptor. The Methanetrisulfonic acid (CAS no: 54322-33-7)was estimated to be not sensitizing to the female CBA Mice . Based on the estimated result Methanetrisulfonic acid (CAS no: 54322-33-7) failed to induce skin sanitization effects and hence is considered to be not sensitizing to female CBA Mice and can be classified under the category ˋ Not Classified’ as per CLP regulation.
Reference
The
prediction was based on dataset comprised from the following
descriptors: "Skin Sensitisation"
Estimation method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
or "b" or "c" or "d" or "e" )
and ("f"
and (
not "g")
)
)
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and ("l"
and "m" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Sulfonic acid by Organic
Functional groups
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Overlapping groups AND Sulfonic
acid by Organic Functional groups (nested)
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] OR
Hydroxy, sulfur attach [-OH] OR Miscellaneous sulfide (=S) or oxide (=O)
OR S(=O)N{-S(=O); P(=O)} OR Suflur {v+4} or {v+6} OR Sulfinic acid
[-S(=O)OH] OR Sulphonate, aliphatic attach [-SO2-O] by Organic
functional groups (US EPA) ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Sulfonic acid AND Sulfonic acid
derivative by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Hydroxy, sulfur attach [-OH] AND Miscellaneous sulfide (=S) or oxide
(=O) AND S(=O)N{-S(=O); P(=O)} AND Suflur {v+4} or {v+6} AND Sulfinic
acid [-S(=O)OH] AND Sulphonate, aliphatic attach [-SO2-O] by Organic
functional groups (US EPA)
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules by DPRA Cysteine peptide depletion
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Low reactive OR Low reactive >>
N-substituted aromatic amides OR Low reactive >> Sulfanilic acid
derivatives OR Moderate reactive OR Moderate reactive >> Activated
1,3,5-triazine derivatives by DPRA Cysteine peptide depletion
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as SN1 OR SN1 >> Iminium Ion
Formation OR SN1 >> Iminium Ion Formation >> Aliphatic tertiary amines
OR SN1 >> Nitrenium Ion formation OR SN1 >> Nitrenium Ion formation >>
Aromatic azo OR SN1 >> Nitrenium Ion formation >> Aromatic nitro OR SN1
>> Nitrenium Ion formation >> Primary aromatic amine OR SN1 >> Nitrenium
Ion formation >> Tertiary aromatic amine OR SN2 OR SN2 >> Episulfonium
Ion Formation OR SN2 >> Episulfonium Ion Formation >> Mustards by DNA
binding by OECD
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Non binder, non cyclic structure
by Estrogen Receptor Binding
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Non binder, impaired OH or NH2 group OR Non binder, MW>500 OR Non
binder, without OH or NH2 group OR Strong binder, NH2 group by Estrogen
Receptor Binding
Domain
logical expression index: "l"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -5.51
Domain
logical expression index: "m"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 1.73
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization:
Various studieshas been investigated for the test chemicalMethanetrisulfonic acid (CAS no: 54322-33-7)to observe the potential for skin sensitization to a greater or lesser extent. The studies are based on in vivo experiments in guinea pigs for target chemical Methanetrisulfonic acid (CAS no: 54322-33-7) and its structurally similar read across substancesMethane Sulfonic Acid (CAS No: 75-75-2) and Methanetrisulfonic acid (CAS no: 54322-33-7).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;
The skin sensitization potential of Methanetrisulfonic acid (CAS no: 54322-33-7) was estimated using OECD QSAR toolbox version 3.3 with log Pow as the primary descriptor. The Methanetrisulfonic acid (CAS no: 54322-33-7) was estimated to be not sensitizing to the female CBA Mice. Based on the estimated result Methanetrisulfonic acid (CAS no: 54322-33-7) failed to induce skin sanitization effects and hence is considered to be not sensitizing to female CBA Mice.
The U.S. National Library of Medicine (2017 ) and U.S. Environmental Protection Agency (2017 ) carried out a Buehler Test was conducted on male and female Hartley guinea pigs for functionally similar read across substance Methane Sulfonic Acid (CAS No: 75-75-2) to assess the skin sensitization effects caused by the chemical.A preliminary study was conducted in order to determine the concentrations to be tested in the main study. In sensitization study, the animals were induced topically with 0.3 ml of test substance (treated group) or with the vehicle (control group) on the left shoulder at concentration of 50% of methane sulfonic acid 70% solution (i.e. 35% of methane sulfonic acid) on day 1.On day 7, the same region received another topical application and on day 14, this same site was treated by a last topical application all these applications lasted approximately 6 hours. Induction frequency was three applications in 14 days, followed by a 24 hour challenge treatment on day 28 at concentration of 25% of methane sulfonic acid 70% solution (i.e. 17.5% of methane sulfonic acid). None of the test animals responded with a skin grade that would have been suggestive of sensitization. Hence the test materialMethane Sulfonic Acid (CAS No: 75-75-2) was considered to be not sensitizing onskin of 20 guinea-pigs.
The above results were further supported by the skin sensitization study ofstructurally similar read across substance Methallyl sulfonate (CAS No:-1561-92-8) by the EUROPEAN COMMISSION – European Chemicals Bureau (2000) in 20 guinea pigs to observed its sensitizing potential according to guinea pig maximization test. During the test, the guinea pigs did not produce any sensitization potential .Thus Methallyl sulfonate(CAS No:-1561-92-8) was considered to be non sensitizing to the skin of guinea pigs.
Thus on the basis of available data for thetarget chemicalMethanetrisulfonic acid (CAS no: 54322-33-7) andits structurally similar read across substancesMethane Sulfonic Acid (CAS No: 75-75-2) and Methanetrisulfonic acid (CAS no: 54322-33-7),it can be concluded thatchemical Methanetrisulfonic acid (CAS no: 54322-33-7) is unable to cause skin sensitization and considered as non skin sensitizer.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The skin sensitization potential of test substance Methanetrisulfonic acid (CAS no: 54322-33-7) and its structurally similar read across substancesMethane Sulfonic Acid (CAS No: 75-75-2) and Methanetrisulfonic acid (CAS no: 54322-33-7) were observed in various studies. From the results obtained from these studies it is concluded that the chemical Methanetrisulfonic acid (CAS no: 54322-33-7)is not likely to cause skin sensitization and hence can be classified as non skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.