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Diss Factsheets
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EC number: 211-661-1 | CAS number: 682-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older, non-GLP proprietary study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- Older study, pre-GLP.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2-bis(allyloxymethyl)butan-1-ol
- EC Number:
- 211-661-1
- EC Name:
- 2,2-bis(allyloxymethyl)butan-1-ol
- Cas Number:
- 682-09-7
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 2,2-bis[(prop-2-en-1-yloxy)methyl]butan-1-ol
- Details on test material:
- Trimethylopropane Diallyl Ether (SN-1461-A), was supplied by Celanese Corporation.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were male and female young adult albino rabbits of the New Zealand strain. All rabbits were acclimated for at least 7 days prior to testing. During the acclimatisation period, the animals were examined with respect to their general health and suitability at test animals.
The rabbits were housed individually in suspended, wire-bottomed cages and maintained on a standard laboratory diet. Food and water were available ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test substance was applied to the backs of four rabbits at a dose level of 3000 mg/kg. The skin of the test site was abraded in half the rabbits (1 male and 1 female). The test site was covered by wrapping the trunk of the animal with impervious plastic sheeting, held in place with tape. Each rabbit was fitted with a lightweight flexible plastic collar throughout the obesrvation period (to prevent ingestion of the test material).
- Duration of exposure:
- 24 hours
- Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- 2 rabbits/sex/dose
- Control animals:
- no
- Details on study design:
- Twenty four hours prior to the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers. The shaved area on each animal was approximately 30% of the total body surface area.
At the end of the exposure period, the test sites were examined for local skin reactions. Observations for mortality, local skin reactions, and behavioural abnormalities were continued for a total of 14 days post-exposure. Initial and final body weights were recorded. A necropsy was conducted on all animals sacrificed at the end of the observation period. - Statistics:
- A formal statistical analysis was not required.
Results and discussion
- Preliminary study:
- No preliminary results.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities during the 14 day observation period.
- Clinical signs:
- other: No abnormal behavioural reactions were noted among any of the rabbits. 24 hours after application, the test sites showed pale red to red well-defined erythema and slight to mild oedema (area definable but not raised more than 1 mm). 7 days after applicati
- Gross pathology:
- No abnormalities were detected at necropsy.
- Other findings:
- No other findings reported.
Any other information on results incl. tables
As no mortalities occurred, the LD50 can be considered to be greater than 3000 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test material was found to be greater than 3000 mg/kg bw under the conditions of this study.
- Executive summary:
The acute dermal toxicity of trimethylopropane diallyl ether was evaluated in 2 male and 2 female New Zealand White rabbits. The undiluted test substance (3000 mg/kg bw) was applied to the shaved skin of the rabbits, and held in place under an occlusive plastic dressing for 24 hours. Two of the test sites (on 1 male and 1 female rabbit) were abraded, and two remained intact. The rabbits were observed for 14 days after the exposure period
.
There were no mortalities during the study, and all rabbits gained weight. There were no clinical signs of toxicity, although the test substance was noted to be slightly irritating to the skin at the application site. No abnormalities were detected at necropsy.
The acute dermal LD50 of TMPDE is therefore greater than 3000 mg/kg bw in rabbits.
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