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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: insufficient individual data reported
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Occupational Asthma caused by triglycidyl isocyanurate (TGIC).
Author:
Piirila, P., Estlander, T., Keskinen, H., Jolanki, R., Laakkonen, A., Pfaffli, P., Tupasela, O., Tuppurainen, M., Nordmann, H
Year:
1997
Bibliographic source:
). Clinical and Experimental Allergy 27, 510-514.
Report Date:
1997

Materials and methods

Study type:
case report
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Investigation of a single case at the Finnish Institute of Occup. Health
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data available except that TGIC at 4% in a powder coating was concerned

Method

Type of population:
occupational
Ethical approval:
not specified
Subjects:
36-year old healthy non-smoking man working for 4 years as spray painter in a metal finishing company using TGIC- containing powder coatings (4% TGIC)
Clinical history:
He developed eczema on hands, face and body, and an occupational allergic eczema caused by TGIC. During weekends and vacation his skin reactions disappeared, but started again as soon as he resumed work.
Controls:
none
Route of administration:
dermal
Details on study design:
Patch tests were performed with paint, 10% and 3.2% in petrolatum, as well as 1%, 0.32% and 0.1% TGIC (>97%), which all gave strong positive reactions.

Results and discussion

Results of examinations:
Spirometry showed slight obstruction, blood eosinophiles and serum IgE was elevated, but skin pricks with common environmental allergens were negative. Respiratory challenge test with a powder coating containing 4% TGIC induced a dual reaction in PEF and late fall (23%) in FEV1, indicative of an occupational asthma.

Any other information on results incl. tables

Some doubts about the methodology remain.

Applicant's summary and conclusion

Conclusions:
It is concluded that TGIC is a contact allergen, and possibly a respiratory allergen.
Executive summary:

Single patient with allergic reactions to TGIC: Patch tests were performed with paint, 10% and 3.2% in petrolatum, as well as 1%, 0.32% and 0.1% TGIC (>97%), which all gave strong positive reactions. Spirometry showed slight obstruction, blood eosinophiles and serum IgE was elevated, but skin pricks with common environmental allergens were negative. Respiratory challenge test with a powder coating containing 4% TGIC induced a dual reaction in PEF and late  fall (23%) in FEV1, indicative of an occupational asthma. Some doubts about the methodology remain. It is concluded that TGIC is a contact allergen, and possibly a respiratory allergen.