Registration Dossier
Registration Dossier
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EC number: 213-668-5 | CAS number: 999-97-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1993
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Only an summary table was available for review.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To investigate the acute toxicity of hexamethyldisilazane via the intraperitoneal route.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,1,3,3,3-hexamethyldisilazane
- EC Number:
- 213-668-5
- EC Name:
- 1,1,1,3,3,3-hexamethyldisilazane
- Cas Number:
- 999-97-3
- Molecular formula:
- C6H19NSi2
- IUPAC Name:
- bis(trimethylsilyl)amine
- Details on test material:
- - Name of test material (as cited in study report): hexamethyldisilazane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 100-1600 mg/kg bw
- No. of animals per sex per dose:
- 10 (total)
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
Any other information on results incl. tables
Time of death: 2.5 hr to 3 days
Weight change over 2 weeks: 7+
Clinical signs: Moderately weak; prostration; tremor; twitching; rough coat; not mating.
Applicant's summary and conclusion
- Conclusions:
- In a tabulated summary of an acute intraperitoneal toxicity study (reliability score 4) the LD50 for 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3, EC 213-668-5) was 800 mg/kg bw.
- Executive summary:
In a tabulated summary of an acute intraperitoneal toxicity study (reliability score 4) the LD50 for 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3, EC 213-668-5)
was 800 mg/kg bw. Time to death was 2.5 hours to three days, and clinical signs were prostration, tremor, twitching, rough coat and 'not mating'.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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