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EC number: 283-392-8
CAS number: 84605-29-8
Repeat dose oral toxicity data is not available for EC 283-392-8, but an OECD 422 study is available for an analogous substance and suitable for read across.
The oral repeat dose
toxicity of an analog substance was evaluated with rats at doses as high
as 160 mg/kg/day for up to 52 consecutive days in accordance with OECD
422. Substance-related toxicity was limited to morbundity, adverse
clinical signs, and epithelial hyperplasia, hyperkeratosis, and
inflammation of the stomach. The
NOAEL for systemic toxicity was 160 mg/kg/day. The
NOEL for portal of entry irritation and related secondary effects
parental toxicity was 40 mg/kg/day.
In accordance to
Directive 67/548/EEC and
the EU CLP (Regulation (EC) No. 1272/2008) classification of this
substance is not required for prolonged exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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