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EC number: 283-392-8
CAS number: 84605-29-8
(see copy of ECHA screening criteria in Appendix A)
Based on read across
from a structurally similar ZDDP compound that was tested for
bioconcentration in fish, this substance is expected to have a low
potential for bioaccumulation (Japanese MITI database, Gazette reference
number 2-22945, “Zinc dialkyl dithiophosphate”;www.safe.nite.go.jp). The
bioconcentration test was conducted in carp for 6 weeks at two
concentrations (0.1 mg/L and 1.0 mg/L) and the resulting BCF values were
all less than 100 -- MITI classified ZDDP as “non or not highly
No empirical test data
for structurally similar substances were found using the OECD Toolbox
and ToxMatch program.
Based on read-across
to soluble complexes of zinc, measured BCF data reported in the U.S.
EPA’s Ecotox Database shows that BCF values in various species including
fish are much less than the screening criteria of the Guidance of 2,000.
Measured data on
structurally similar substances as identified by the CAESAR database
shows BCF values less than 1,000 (CAESAR dataset molecules ID 405 and
on bioaccumulation potential for this UVCB substance can also be taken
from Environment Canada’s screening assessment (January 2010) for the
ZDDP EC#2186799 (CAS#2215-35-2), which determined that the “substance
has a low potential to accumulate in the lipid tissues of organisms”. Based
on Environment Canada’s analysis, modeled data in fish resulted in fish
BCF values less than 100 using the OASIS Forecast 2005 and BCFWIN models.
Based on their
analysis of available evidence, Environment Canada concluded that the
ZDDP studied “is expected to have low bioaccumulation potential due to
its physical and chemical properties”, in agreement with conclusions of
the U.S. EPA which considers this group of substances to have low
bioaccumulation potential (US EPA 2008).
QSAR predicted data
from structurally similar (>90% Tanimoto index) substances found in the
OECD toolbox had BCF values significantly less than the screening
CAS number provided by the OECD Toolbox for this structurally similar
substance was #7405-05-2.
The OECD Toolbox also
predicts No binding to protein for this substance. Protein
binding has been shown to contribute to the bioconcentration potential
of substances in aquatic species (Fairbrother et al. 2007;
Cowan-Ellsberry et al. 2008; Franke 1996; Legierse et al. 1998;
Tremolada et al. 2009; Veltman et al. 2006). Metal
substances may form complexes with proteins for distribution,
sequestration, and excretion depending on the substance’s relative
bioaccessibility and bioavailability.
Based on the measured
log Kow (per OECD 107 guidelines) value of 0.56, this substance is not
bioaccumulative based on the ECHA octanol water partitioning coefficient
mechanisms for uptake and depuration of compounds containing metals are
complex and variable.
and discussion of bioaccumulation
Based on the weight of
evidence from read across to structurally similar ZDDP substances with
BCF data in fish (from Japanese MITI data, US EPA database, CAESAR
database), measured Low Kow data, and QSAR predictions, this substance
is expected to have low bioaccumulation potential. This
substance does not meet the criteria of concern for bioaccumulation.
Results for Substance
Screening Assignment based on Data for Substance
Octanol-water partitioning coefficient
Log Kow <4.5
Log Kow 0.56
Structural similarity or class of chemicals
Similarity to class of chemicals known to accumulate in living organisms ?
Material is not structurally similar to any known materials that fulfill the screening criteria
BCF in Fish
CAESAR read across from structurally similar substances with experimental BCF values
Measured BCF less than 100 in carp for structurally similar ZDDP substance as reported in Japanese MITI database
EPA Ecotox Database for Zinc compounds
Environment’s BCF predictions using OASIS and BCFWIN models for a surrogate ZDDP
* Based on criterion
described in ECHA 2008, “Guidance on information requirements and
chemical safety assessment. Chapter
R.11: PBT Assessment”
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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