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Diss Factsheets
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EC number: 203-213-9 | CAS number: 104-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from a peer-reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Sensitization Potential of Some Perfume Ingredients Tested Using a Modified Draize Procedure
- Author:
- D.W. Sharp
- Year:
- 1 978
- Bibliographic source:
- Toxicology, 9 (1978) 261-271
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- other: Modified Draize test
- Justification for non-LLNA method:
- No Data Available
Test material
- Reference substance name:
- Cinnamaldehyde
- EC Number:
- 203-213-9
- EC Name:
- Cinnamaldehyde
- Cas Number:
- 104-55-2
- Molecular formula:
- C9H8O
- IUPAC Name:
- 3-phenylacrylaldehyde
- Details on test material:
- Details on test material
- Name of test material (as cited in study report): Cinnamic aldehyde
- Molecular formula (if other than submission substance): C9H8O
- Molecular weight (if other than submission substance): 132.1612 g/mol
- Substance type: Organic
- Physical state: No data available
Purity: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Bred in lab colony
- Age at study initiation: No data available
- Weight at study initiation: 350 g
- Housing: During testing they were housed in wire mesh cages in pairs of the same sex
- Diet (e.g. ad libitum): pelleted guinea pig diet, cabbage, hay ad libitum
- Water (e.g. ad libitum): water ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: No Data Available
- Concentration / amount:
- Injection challenge concentration: 0.25%
Application challenge concentration: 20%
Challengeopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: No Data Available
- Concentration / amount:
- Injection challenge concentration: 0.25%
Application challenge concentration: 20%
- No. of animals per dose:
- 4 males and 6 females or vice-versa
Control animals: Yes, used during the challenge exposure - Details on study design:
- Details on study design
RANGE FINDING TESTS: No data available
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 4
- Exposure period: No data available
- Test groups: 10
- Control group: used
- Site: at 4 sites which overlie the 2 auxillary and 2 inguinal lymph nodes.
- Frequency of applications: Once
- Duration: 14 days
- Concentrations: 4 X 0.1 ml intradermal injections at 2.5 X ICC
B. CHALLENGE EXPOSURE
- No. of exposures: 2
- Day(s) of challenge: 1 day
- Exposure period: 24 hrs
- Test groups: 10
- Control group: At each challenge with controls, 4 previously untreated animals of the same sex and similar weight to the test animals were treated intradermally and topically on opposite flanks with 0.1 ml aliquots of test substance at the ICC and ACC respectively.
- Site: intradermally in one flank and topically in the other flank
- Concentrations:
Injection challenge concentration: 0.25%
Application challenge concentration: 20%
- Evaluation (hr after challenge): 24 hrs
OTHER: apparent sensitization reactions were confirmed 7 day later by a second challenge with controls included - Challenge controls:
- No Data Available
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- No Data Available
In vivo (non-LLNA)
Results
- Reading:
- other: Sensitizing (after 2 sensitization treatments)
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- Injection challenge concentration: 0.25% Application challenge concentration: 20%
- Total no. in group:
- 10
- Clinical observations:
- No data available
- Remarks on result:
- positive indication of skin sensitisation
- Remarks:
- Reading: other: Sensitizing (after 2 sensitization treatments). . Hours after challenge: 24.0. Group: test group. Dose level: Injection challenge concentration: 0.25% Application challenge concentration: 20% . Total no. in groups: 10.0. Clinical observations: No data available.
Applicant's summary and conclusion
- Interpretation of results:
- other: The test chemical was considered to be sensitizing.
- Conclusions:
- Based on all the available data, it was concluded that the test chemical was observed to be a skin sensitizer to guinea pigs at the challenge concentrations tested.
- Executive summary:
A modified Draize procedure was used to identify, the test chemical for its potential to induce allergic contact dermatitis in guinea pigs. Induction exposure included intradermal injections at 4 sites with 0.1 mL aliquots of test substance at 2.5 times the ICC. Challenge exposure included intradermal induction (ICC) at a dose of 0.25% and topical application (ACC) at a concentration of 20%. In the absence of sensitization reactions at first challenge the induction and challenge procedures were repeated, but this time a comfirmatory challenge with controls was included irrespective of any apparent sensitization reactions at the previous challenge. Based on all the available data, it was concluded that the test chemical was observed to be a skin sensitizer to guinea pigs at the challenge concentrations tested.
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