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EC number: 260-828-5 | CAS number: 57583-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500 "Method of testing toxic substances - Acute dermal toxicity (single exposure)"
- Deviations:
- yes
- Remarks:
- Study used less than the recommended number of test animals at each dose level; three male and two female rabbits weighed more than 3000 grams
- Principles of method if other than guideline:
- New Zealand White rabbits, initial body weights 2611 to 3836 g, were used to evaluate the acute dermal toxicity of the test substance. Test animals were caged individually under a 12-hour light/12-hour dark cycle and were acclimated for at least 32 days prior to testing. Food and water were provided ad libitum. Both sexes were initially tested at dose levels of 1000 and 2150 mg/kg; males were then treated with 4640 and 10 000 mg/kg and females were treated with 215 and 464 mg/kg, based on mortality data from the initial doses. Prior to dosing, the trunk of each animal was shaved and the skin of half the animals in each dose group was abraded. The test material was applied undiluted via occlusive patch around the trunk of each animal and wrapped in a layer of gauze and tape. Animals were restrained and observed for signs of systemic toxicity over the 24-hour exposure period. After 24 hours, the patches were removed, the exposed skin was cleaned, and test animals were observed daily for signs of irritation, systemic toxicity and mortality for 14 days. Animals were weighed and necropsied at death; surviving animals were euthanised, weighed and necropsied at the end of the observation period. Mortality data were evaluated by the method of Weil (1952, Biometrics, 8:249-263).
- GLP compliance:
- not specified
- Test type:
- other: Method of testing toxic substances- acute dermal toxicity
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
- EC Number:
- 260-828-5
- EC Name:
- 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
- Cas Number:
- 57583-34-3
- Molecular formula:
- C31H60O6S3Sn
- IUPAC Name:
- 2-ethylhexyl 10-ethyl-4-({2-[(2-ethylhexyl)oxy]-2-oxoethyl}sulfanyl)-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecan-1-oate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 1379-20
- Storage condition of test material: room temperature in a closed glass container
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Clerco Research Farm
- Weight at study initiation: 2611 to 3836 grams
- Fasting period before study: no data
- Housing: housed individually in wire mesh suspension cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 32 days prior to dosing
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
IN-LIFE DATES: From: February 21, 1983 To: March 15, 1983
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- % coverage: no data
- Type of wrap if used: sleeve of rubber dental damming which was wrapped around the trunk of each rabbit and secured with staples. An outer layer of gauze and tape and was also wrapped around the trunk of each animal.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gentle sponging with a moist towel
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Dosages were 215, 464, 1000 and 2150 mg/kg in females; 1000, 2150, 4640 and 10 000 mg/kg in males. Both sexes were initially treated with dosages of 1000 and 2150 mg/kg. Males were then treated with dosages 4640 and 10,000 mg/kg and females were treated with dosages of 215 and 464 mg/kg.
- Constant volume or concentration used: concentration
VEHICLE
-No vehicle used - Duration of exposure:
- 24 hours
- Doses:
- 1000, 2150, 4640, and 10 000 mg/kg (males);
215, 464, 1000, and 2150 mg/kg (females) - No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animlas were observed for gross signs of systemic toxicity, dermal irritation, and death for 14 days. Animals were weighed at the end of the 14-day observation period.
- Necropsy of survivors performed: yes - Statistics:
- no data
Results and discussion
- Preliminary study:
- not applicable
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- 95% CL:
- 460 - 2 020
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 150 mg/kg bw
- 95% CL:
- 1 000 - 4 620
- Mortality:
- Cumulative mortality (total number of deaths/total number dosed), by sex and dose level:
215 mg/kg: 0/2 females
464 mg/kg: 0/2 females
1000 mg/kg: 1/2 females (day 3); 0/2 males
2150 mg/kg: 2/2 females (days 3, 6); 1/2 males (day 4)
4640 mg/kg: 2/2 males (days 4, 6)
10 000 mg/kg: 2/2 males (day 3) - Clinical signs:
- other: Frequently observed clinical signs included death, uncoordinated movements, and shaking and hypersensitivity to external stimuli. All clinical sign disappeared in surviving animals by the end of the exposure period. The most frequently observed irritat
- Gross pathology:
- Gross necropsy results for animals that died during observation included irritated intestines, blanched stomach, reddened lungs, pale or congested kidneys, and oral, ocular, and/or nasal discharge. Necropsies of surviving animals at the end of the study revealed no relevant findings.
- Other findings:
- Upon removal of the binders from the animals, the binder and the exposed area were dry with no sample apparent on most of the animals. The 10 000 mg/kg males and one 2150 mg/kg female had moist sites with sample apparent after application.
Any other information on results incl. tables
Females- Body Weight (g)Animal no. Skin condition Day 0 Day 15 Body Weight Gain Day 0-15 (g)215 mg/kg15 abraded 2904 3209 30516 intact 3201 3568 367Mean (SD) 3052 (210) 3388 (254) 336 (44)464 mg/kg11 abraded 2783 2895 11212 intact 2758 3065 307Mean (SD) 2770 (18) 2980 (55) 210 (138)1000 mg/kg3 abraded 3280 rabbit died prior to observation4 intact 2649 3051 402Mean (SD) 2964 (446) 3051 4022150 mg/kg7 abraded 2955 rabbit died prior to observation8 intact 2629 rabbit died prior to observationMean (SD) 2792 (231)
Applicant's summary and conclusion
- Interpretation of results:
- other: Classified as Category 3 in accordance with EU criteria
- Conclusions:
- The acute dermal LD50 value was found to be 2.15 g/kg in male and 1.0 g/kg in female New Zealand White rabbits.
- Executive summary:
The test material was applied undiluted to the skin of sixteen New Zealand White rabbits (two males and two females per dose level) at dosages of 0.215, 0.464, 1.0, 2.15 (females) or 1.0, 2.15, 4.64 and 10.0 g/kg (males) for 24 hours. Animals were observed for gross signs of systemic toxicity, dermal irritation, and death for 14 days. At the end of the 14day observation period, survivors were weighed, killed, and given a gross necropsy.
Deaths occurred between days 3 and 6 of the observation period. Clinical changes associated with the test material included death, shaking behavior, uncoordinated movement, ataxia and hypersensitivity. The most frequently observed irritative effects included erythema, edema, atonia, desquamation and blanching. Gross necropsies performed on the animals that died revealed irritated gastrointestinal tracts, pale or congested kidneys and reddened lungs. Gross necropsies performed on survivors at the end of the study revealed no gross alterations. The acute dermal LD50 value was found to be 2.15 g/kg in male and 1.0 g/kg in female New Zealand White rabbits.
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