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EC number: 203-820-9 | CAS number: 110-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to test guidelines and in accordance with GLP
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
- Principles of method if other than guideline:
- This study was conducted to determine the relative dermal bioavailability (absorption), distribution, metabolism, and excretion (ADME) of diisopropanolamine (DIPA). Groups of 4 female Fischer 344 rats received a dermal application of 19.5 mg/ kg 14C-DIPA in acetone to an area of 1 cm2 on the back and covered with a bandage. Time-course blood and excreta were collected and radioactivity determined. Urine was analyzed for DIPA and monoisopropanolamine (MIPA).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1´-iminodipropan-2-ol
- IUPAC Name:
- 1,1´-iminodipropan-2-ol
- Reference substance name:
- 1,1'-iminodipropan-2-ol
- EC Number:
- 203-820-9
- EC Name:
- 1,1'-iminodipropan-2-ol
- Cas Number:
- 110-97-4
- Molecular formula:
- C6H15NO2
- IUPAC Name:
- 1,1'-iminodipropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Diisopropanolamine
- Analytical purity: 99 %
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Inc. (Kingston, NY)
- Age at study initiation: 10 weeks
- Weight at study initiation: 148–162 g
- Housing: two per cage
- Individual metabolism cages: yes/no
- Diet: Purina Certified Rodent Chow #5002 (Ralston Purina Co.,) ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±2°C
- Humidity (%): 40–60 %
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- acetone
- Duration of exposure:
- 48 h
- Doses:
- 19.5 mg/kg bw
- No. of animals per group:
- 4
- Control animals:
- no
- Details on study design:
- TEST SITE
- Preparation of test site: shaved
- Area of exposure: 1 cm2
- Type of cover / wrap if used: 4 cm2 piece of Teflon and secured in place with Conform adhesive bandages
SITE PROTECTION / USE OF RESTRAINERS FOR PREVENTING INGESTION: yes: each rat was fitted with a rodent jacket
SAMPLE COLLECTION
- Collection of blood: 0.5, 1, 2, 4, 6, 12, 24, 36 and 48 h post-dosing
- Collection of urine and faeces: 6, 12, 24 and 48 h post-dosing (urine); feces: at 12 h intervals
- Collection of expired air: 12 h intervals
ANALYSIS
- Method type(s) for identification: Liquid scintillation counting
Results and discussion
Percutaneous absorption
- Dose:
- 19.5 mg/kg bw
- Parameter:
- percentage
- Absorption:
- ca. 20 %
- Remarks on result:
- other: 48 h
- Remarks:
- Total recovery: 69%, of which 26% was recovered from protective appliciances and 24% from the surface of the dosed skin
Any other information on results incl. tables
The total recovery of the dermally applied dose was 69.2 ± 17.0%. The recovery of the applied radioactivity from 3 out of 4 rats was between 71% and 80%; recovery in one of the rats was only 48%. Most of the administered radioactivity was recovered from the protective appliances (Teflon patch, template, bandage, and jacket) accounting for 25.7 ± 11.2% and from the surface of the dosed skin (23.7 ± 4.5%). At the end of the study (48 h post-application), 3.5 ± 3.5% of the dose was found in skin remote from the site of the dosing with levels in 2 of 4 rats 0.5% and the other 2 between 5% and 8% of the dose. Concentration of 14C-DIPA-derived radioactivity was 0.1% in liver and kidney and 0.01% in fat. A total of 1.1 ± 0.4% of the applied dose was found in carcass. The dermally applied DIPA was not volatile or metabolized to CO2; 0.2% of the dosed radioactivity was trapped in charcoal or monoethanolamine:1-methoxy-2-propanol solution. A total of 14.6% of the applied radioactivity was found in excreta (urine + feces + final cage wash). Consistent with the intravenous data, urine was the major route for the excretion of 14C-DIPA constituting 99% of the total excretion (urine + final cage wash + feces), fecal elimination of 14C-DIPA was 0.2% or 1.2% of the total radioactivity recovered in excreta.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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