Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-389-8 | CAS number: 3457-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a GLP guideline study (OECD 301 F)
- Reason / purpose for cross-reference:
- reference to same study
- Guideline:
- other: OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- yes
- Remarks:
- extended period up to 58 days
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- Because of a low hydro solubility of the test item, 25 mg of TERT-BUTYL CUMYL PEROXIDE are directly pour in test flask, corresponding to a theoretical O2 mass of 65.3 mg per flask (ThOD 2.612 mg O2/mg). A parent solution of sodium benzoate in the dilution water to 2.5 mg/mL, was used in a proportion of 10 mL for 250 mL of dilution water, i.e. 25 mg, corresponding to a theoretical O2 mass of 41.65 mg perflask (ThOD 1.67 mg O2/mg). In the inhibition monitoring flask, equivalent quantities of test and reference items are introduced. For this flask, the corresponding theoretical mass of O2 is 107 mg per flask.
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- The inoculum came from the activated sludge of the biological wastewater treatment plant from Abidos (France, 64). The effluent, obtained one day before seeding the flasks, was centrifuged at approximately 20 °C for 10 min at 1000 g; the base was re-suspended in dilution water in order to keep the same concentration. The inoculum was preconditioned (aeration) until the flasks were inoculated. The amount of dry material in the inoculum, determined by desiccation at 105 °C until a constant weight is obtained, was 4.41 g/L.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 56 d
- Hardness:
- No data
- Test temperature:
- 22 ± 1°C
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- Not relevant
- Nominal and measured concentrations:
- Nominal concentration 100 mg/L
- Details on test conditions:
- This test was performed according to OECD 301F with the following conditions:
The flasks were installed in the respirometer where the stirring system was started. After a waiting period of approximately 2 hour, which is necessary to reach the thermal equilibrium of the solutions at a temperature of 22 ± 1°C, the aerated inoculum, pr econditioned if required, is added to all the flasks that are then plugged. - Reference substance (positive control):
- no
- Duration:
- 58 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- In the toxicity control flasks, containing both the reference item and TERT-BUTYL CUMYL PEROXIDE the percentage biodegradation reached 37.8 % after 14 days. Since this value is higher than 25%, the test item is not inhibitory for inoculum.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- TERT-BUTYL CUMYL PEROXIDE is not toxic to microorganisms at the 100 mg/L concentration (NOEC = 100 mg/L, nominal concentration).
- Executive summary:
The toxicity of TERT-BUTYL CUMYL PEROXIDE to microorganism was estimated in a ready biodegradability study performed according to OECD 301F guideline and GLP requirements.
In the toxicity control flasks, containing both the reference item and TERT-BUTYL CUMYL PEROXIDE the percentage biodegradation reached 37.8 % after 14 days. Since this value is higher than 25%, the test item is not inhibitory for inoculum at the 100 mg/L concentration (NOEC = 100 mg/L, nominal concentration).
Reference
Description of key information
TERT-BUTYL CUMYL PEROXIDE is not toxic to microorganisms at the 100 mg/L concentration (NOEC = 100 mg/L, nominal concentration).
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
The toxicity of TERT-BUTYL CUMYL PEROXIDE to microorganism was estimated in a ready biodegradability study performed according to OECD 301F guideline and GLP requirements.
In the toxicity control flasks, containing both the reference item and TERT-BUTYL CUMYL PEROXIDE the percentage biodegradation reached 37.8 % after 14 days. Since this value is higher than 25%, the test item is not inhibitory for inoculum at the 100 mg/L concentration (NOEC = 100 mg/L, nominal concentration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)